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Hyperpolarized 129 Xe Magnetic Resonance Imaging Sensor for H 2 S
Author(s) -
Yang Shengjun,
Yuan Yaping,
Jiang Weiping,
Ren Lili,
Deng He,
Bouchard Louis S.,
Zhou Xin,
Liu Maili
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605768
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , xenon , chemistry , resonance (particle physics) , physics , atomic physics , medicine , radiology
A new magnetic resonance imaging (MRI) molecular sensor for hydrogen sulfide detection and imaging using the nuclear spin resonance of hyperpolarized 129 Xe is developed. The designed MRI sensor employs cryptophane for NMR sensing, together with an azide group serving as a reaction site. It demonstrates a “proof‐of‐concept” that a fluorescent H 2 S probe can be linked to a xenon‐binding cryptophane and thereby converted into an MRI probe, which could provide a very generalizable template.