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Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using an Air‐ and Moisture‐Stable Iron Racemization Catalyst
Author(s) -
Gustafson Karl P. J.,
Guðmundsson Arnar,
Lewis Kayla,
Bäckvall JanE.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605754
Subject(s) - racemization , kinetic resolution , catalysis , lipase , moisture , kinetic energy , chemistry , resolution (logic) , organic chemistry , chemical engineering , enantioselective synthesis , enzyme , computer science , engineering , physics , quantum mechanics , artificial intelligence
Abstract Herein, we report on a metalloenzymatic dynamic kinetic resolution of sec ‐alcohols employing an iron‐based racemization catalyst together with a lipase. The iron catalyst was evaluated in racemization and then used in dynamic kinetic resolution of a number of sec ‐alcohols to give enantiomerically pure products in good to high yields. The iron catalyst is air and moisture stable and is readily accessible.