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Gaining Synthetic Appreciation for the Gedunin ABC Ring System
Author(s) -
Pinkerton David M.,
Vanden Berg Timothy J.,
Bernhardt Paul V.,
Williams Craig M.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605751
Subject(s) - ring (chemistry) , perspective (graphical) , natural product , computer science , nanotechnology , chemistry , stereochemistry , materials science , artificial intelligence , organic chemistry
Gedunin, first isolated in 1960, displays a remarkable range of biological activity, but has yet to receive dedicated synthetic attention from a ground up construction perspective. Presented herein is a successfully executed approach to the fully functionalized ABC ring system of this challengingly complex natural product.