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Rh‐Catalyzed Chemo‐ and Enantioselective Hydrogenation of Allylic Hydrazones
Author(s) -
Hu Qiupeng,
Hu Yanhua,
Liu Yang,
Zhang Zhenfeng,
Liu Yangang,
Zhang Wanbin
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605579
Subject(s) - allylic rearrangement , enantioselective synthesis , stereocenter , rhodium , amine gas treating , catalysis , chemistry , combinatorial chemistry , organic chemistry
A highly efficient P‐stereogenic diphosphine–rhodium complex was applied to the chemo‐ and enantioselective hydrogenation of allylic hydrazones for the synthesis of chiral allylic hydrazines in 89–96 % yields and with 82–99 % ee values. This methodology was successfully applied to the preparation of versatile chiral allylic amine derivatives.