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Cover Picture: Asymmetric Catalytic Aza‐Diels–Alder/Ring‐Closing Cascade Reaction Forming Bicyclic Azaheterocycles by Trienamine Catalysis (Chem. Eur. J. 1/2017)
Author(s) -
Li Yang,
Barløse Casper,
Jørgensen Julie,
Carlsen Bjørn Dreiø,
Jørgensen Karl Anker
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605561
Subject(s) - zipper , bicyclic molecule , chemistry , silyl ether , catalysis , molecule , hydrazone , stereochemistry , combinatorial chemistry , silylation , organic chemistry , mathematics , algorithm
This artwork presents the basic reaction concept of the asymmetric catalytic aza‐Diels–Alder/ring‐closing cascade by the operation mode of a zipper. The two molecules (red: 2,4‐dienal; blue: hydrazone) in this reaction are mosaicked into the two chains of the zipper. The chiral slider, the diarylprolinol‐silyl ether catalyst, zips together the two molecules by sliding the hand down the chains forming the bicyclic aza‐heterocyclic products in a highly stereoselective manner. More information can be found in the Communication by K. A. Jørgensen et al. on page 38 ff.