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Isolation of a Reactive Cyclopropane Intermediate via a Unique Catalyst‐Free Spontaneous Cyclopropanation Step at 0 °C
Author(s) -
Braunschweig Holger,
Dewhurst Rian D.,
Ewing William C.,
KuntzeFechner Maximilian W.,
Schäfer Marius
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605514
Subject(s) - cyclopropanation , cyclopropane , catalysis , cascade , bicyclic molecule , chemistry , isolation (microbiology) , photochemistry , stereochemistry , organic chemistry , ring (chemistry) , biology , chromatography , microbiology and biotechnology
A remarkably mild, catalyst‐free cyclopropanation reaction is confirmed by low‐temperature isolation of a fused bicyclic cyclopropane intermediate. This intermediate is one of two that were isolated and fully characterised in a three‐step temperature‐controllable reaction cascade.