Vicinal Difluoroalkylation and Aminosulfonylation of Alkynes under Photoinduced Conditions | Zendy

Xiang Yuanchao | Zendy; Li Yuewen | Zendy; Kuang Yunyan | Zendy; Wu Jie | Zendy

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Vicinal Difluoroalkylation and Aminosulfonylation of Alkynes under Photoinduced Conditions

Author(s) -

Xiang Yuanchao,

Li Yuewen,

Kuang Yunyan,

Wu Jie

Publication year - 2017

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201605336

Subject(s) - vicinal , chemistry , organic chemistry

A photoinduced vicinal difluoroalkylation and aminosulfonylation of alkynes under photocatalysis was realized. The combination of ethyl 2‐bromo‐2,2‐difluoroacetate, alkynes, and DABCO⋅(SO 2 ) 2 with hydrazines, catalyzed by 9‐mes‐10‐methyl acridinium perchlorate in the presence of visible light, afforded ( E )‐ethyl 2,2‐difluoro‐4‐aryl‐4‐sulfamoylbut‐3‐enoates in good yields with high stereoselectivity. This four‐component reaction proceeds through radical addition with the insertion of sulfur dioxide.

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