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Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals
Author(s) -
AnayaPlaza Eduardo,
van de Winckel Eveline,
Mikkilä Joona,
Malho JaniMarkus,
Ikkala Olli,
Gulías Oscar,
BresolíObach Roger,
Agut Montserrat,
ll Santi,
Torres Tomás,
Kostiainen Mauri A.,
de la Escosura Andrés
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605285
Subject(s) - cationic polymerization , supramolecular chemistry , covalent bond , photosensitizer , phthalocyanine , chemistry , nanostructure , cellulose triacetate , nanotechnology , cellulose , materials science , combinatorial chemistry , polymer chemistry , photochemistry , organic chemistry , molecule
The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non‐covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non‐covalent biohybrids show strong photodynamic activity against S. aureus and E. coli , representative examples of Gram‐positive and Gram‐negative bacteria, respectively, and C. albicans , a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.