Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and  B – Z  DNA Transition | Zendy

Kawara Kensuke | Zendy; Tsuji Genichiro | Zendy; Taniguchi Yosuke | Zendy; Sasaki Shigeki | Zendy

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Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B – Z DNA Transition

Author(s) -

Kawara Kensuke,

Tsuji Genichiro,

Taniguchi Yosuke,

Sasaki Shigeki

Publication year - 2017

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201605276

Subject(s) - helicene , chirality (physics) , helicity , spermine , stereochemistry , dna , ligand (biochemistry) , chemistry , z dna , axial chirality , crystallography , physics , receptor , enantioselective synthesis , biochemistry , molecule , chiral symmetry , quantum mechanics , enzyme , nambu–jona lasinio model , organic chemistry , quark , catalysis

The 2,13‐dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B ‐DNA by the accompanying induction of its ( P )‐chirality together with the B ‐to‐ Z helicity change of the duplex DNA, [(dC‐dG) 3 ] 2 . The ( P )‐chirality of the bound 8 b , in turn, transitioned to the ( M )‐chirality according to the Z ‐helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.

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