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Nickel‐Catalyzed N‐Arylation of Primary Amides and Lactams with Activated (Hetero)aryl Electrophiles
Author(s) -
Lavoie Christopher M.,
MacQueen Preston M.,
Stradiotto Mark
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605095
Subject(s) - aryl , electrophile , catalysis , chemistry , bromide , nickel , halide , trifluoromethanesulfonate , primary (astronomy) , chloride , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl , physics , astronomy
The first nickel‐catalyzed N‐arylation of amides with (hetero)aryl (pseudo)halides is reported, enabled by use of the air‐stable pre‐catalyst (PAd‐DalPhos)Ni( o ‐tolyl)Cl ( C1 ). A range of structurally diverse primary amides and lactams were cross‐coupled successfully with activated (hetero)aryl chloride, bromide, triflate, tosylate, mesylate, and sulfamate electrophiles.