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Inside Cover: Phosphite‐Thiother Ligands Derived from Carbohydrates allow the Enantioswitchable Hydrogenation of Cyclic β‐Enamides by using either Rh or Ir Catalysts (Chem. Eur. J. 4/2017)
Author(s) -
Margalef Jèssica,
Pàmies Oscar,
Diéguez Montserrat
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605038
Subject(s) - thioether , catalysis , chemistry , ligand (biochemistry) , enantiomer , asymmetric hydrogenation , combinatorial chemistry , organic chemistry , medicinal chemistry , enantioselective synthesis , biochemistry , receptor
Both enantiomers of 2‐aminotetralines and 3‐aminochromanes are easily accessible via asymmetric hydrogenation by simply switching from Rh to Ir. The chiral information is provided by a phosphite‐thioether ligand, with a simple architecture, derived from d ‐mannitol. This picture illustrates how the chiral pool can be used to synthesize these phosphite‐thioether ligands that in combination with either Rh‐ or Ir‐catalyst precursors allow the efficient enantioswitchable hydrogenation of cyclic β‐enamides. More information can be found in the Full Paper by O. Pàmies and M. Diéguez et al. on page 813 ff.