Premium
Constructing Implantable SrTiO 3 :Yb,Ho Nanofibers for NIR‐Triggered and Optically Monitored Chemotherapy
Author(s) -
Fu Yike,
Fang Chao,
Ren Zhaohui,
Xu Gang,
Li Xiang,
Han Gaorong
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604956
Subject(s) - polyacrylic acid , materials science , förster resonance energy transfer , drug delivery , doxorubicin , nanofiber , nanotechnology , fluorescence , biophysics , polymer , chemotherapy , optics , medicine , physics , surgery , composite material , biology
Light‐responsive and photoluminescent (PL) drug‐delivery platforms have sparked fascinating advancements in personalized tumor chemotherapy due to their unique characteristics in biological imaging and manipulated release kinetics. Herein, implantable Yb 3+ and Ho 3+ co‐doped strontium titanate (SrTiO 3 :Yb,Ho) nanofibers were synthesized and decorated on the surface with polyacrylic acid (PAA) molecules. The preliminary in vitro assay confirmed that this implantable fibrous mesh presented sound cytocompatibility. The PAA surface decoration improved the loading capacity of an anticancer drug (doxorubicin (DOX)) and effectively prevented a daunting burst release in a neutral aqueous environment. Owing to the electrostatic bond between PAA and DOX molecules, low‐pH microenvironments and NIR ( λ =808 nm) irradiation both induced significantly accelerated DOX release and consequently enhanced the local cancer‐cell‐killing effect. Additionally, the ratio of green‐to‐red emission ( I 545 / I 655 ) from the SrTiO 3 :Yb,Ho‐PAA fibers responded effectively to the DOX release progress and dosage due to a fluorescence resonance energy transfer (FRET) effect. This unique characteristic enabled optical monitoring of the delivery progress in a timely manner. These SrTiO 3 :Yb,Ho‐PAA nanofibers, with precise dual‐triggering and optical monitoring of DOX release, are expected to serve as a new implantable drug delivery platform for personalized chemotherapy in the future.