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Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols
Author(s) -
Shi Liyang,
Tan Xuefeng,
Long Jiao,
Xiong Xiong,
Yang Song,
Xue Peng,
Lv Hui,
Zhang Xumu
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604904
Subject(s) - ruthenium , catalysis , chemistry , denticity , combinatorial chemistry , amide , organic chemistry , metal
Abstract A highly chemoselective and reactive direct catalytic reduction of various amides to amines and alcohols was developed by using a tetradentate ruthenium complex. The catalytic system showed excellent activity (turnover numbers up to 19 600) and great functional group tolerance under mild reaction conditions, compared to several bidentate and tridentate ruthenium‐catalyzed systems.