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The First Casbane Hydroperoxides EBC‐304 and EBC‐320 from the Australian Rainforest
Author(s) -
Maslovskaya Lidiya A.,
Savchenko Andrei I.,
Gordon Victoria A.,
Reddell Paul W.,
Pierce Carly J.,
Parsons Peter G.,
Williams Craig M.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604674
Subject(s) - rainforest , croton , chemistry , botany , organic chemistry , biology
Investigation of the Australian rainforest plant Croton insularis led to isolation of the first casbane hydroperoxide diterpenes EBC‐304 and EBC‐320. Extensive DFT and electronic circular dichroism (ECD) calculations in combination with 2D NMR spectroscopy determined the absolute configurations. EBC‐304 and EBC‐320 both display significant cytotoxicity.