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N ‐Methylanilines as Simple and Efficient Promoters for Radical‐Type Cross‐Coupling Reactions of Aryl Iodides
Author(s) -
Yang Huan,
Zhang Li,
Jiao Lei
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604602
Subject(s) - aryl , radical , aryl radical , chemistry , halogen , halide , coupling reaction , combinatorial chemistry , polymer chemistry , photochemistry , organic chemistry , catalysis , alkyl
Activation of the carbon–halogen bonds in aryl halides is a key step in transition‐metal‐free cross‐coupling reactions. In this paper, a new and efficient radical initiation system for the activation of iodoarenes to produce aryl radicals was discovered, which employs the combination of N ‐methylanilines and t BuOK. This radical initiation system is robust and versatile, enabling various types of aryl‐radical‐related reactions.