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Recent Progress Toward the Synthesis of Trifluoromethyl‐ and Difluoromethyl‐Substituted Cyclopropanes
Author(s) -
Bos Maxence,
Poisson Thomas,
Pannecoucke Xavier,
Charette André B.,
Jubault Philippe
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604564
Subject(s) - trifluoromethyl , ring (chemistry) , cycloaddition , chemistry , cyclopropane , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl
This Minireview describes recent advances toward the synthesis of trifluoromethyl‐ and difluoromethyl‐substituted cyclopropanes. Synthetic methodologies using [2+1] cycloaddition, ring‐contraction, and ring‐closure cyclopropanations since 2010 are reported.