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Functional Group Interconversion: Decarbonylative Borylation of Esters for the Synthesis of Organoboronates
Author(s) -
Guo Lin,
Rueping Magnus
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604504
Subject(s) - borylation , functional group , chemistry , aryl , substrate (aquarium) , reactivity (psychology) , alkyl , combinatorial chemistry , group (periodic table) , organic chemistry , biology , medicine , ecology , alternative medicine , pathology , polymer
A new and efficient nickel‐catalyzed decarbonylative borylation reaction of carboxylic acid esters with bis(pinacolato)‐diboron has been developed. This transformation allows access to structurally diverse aryl as well as alkenyl and alkyl boronate esters with high reactivity, broad substrate scope, and excellent functional‐group tolerance. Further experiments show that this protocol can be carried out on a gram scale and applied to orthogonal synthetic strategies.