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Csp 3 −H Activation without Chelation Assistance in an Iridium Pincer Complex Forming Cyclometallated Products
Author(s) -
Ahlstrand David A.,
Polukeev Alexey V.,
Marcos Rocío,
Ahlquist Mårten S. G.,
Wendt Ola F.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604469
Subject(s) - pincer movement , iridium , pyridine , chemistry , chelation , medicinal chemistry , reductive elimination , catalysis , inorganic chemistry , organic chemistry
Cyclometallation of 8‐methylquinoline and 2‐(dimethylamino)‐pyridine in an iridium‐based pincer complex is described. The C−H activation of 2‐(dimethylamino)pyridine is not chelation assisted, which has not been described before for Csp 3 −H bonds in cyclometallation reactions. The mechanism of the cyclometallation of 2‐(dimethylamino)pyridine was studied by DFT calculations and kinetic measurements.