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Inside Back Cover: A Gold(I)‐Catalyzed Domino Coupling of Alcohols with Allenes Enables the Synthesis of Highly Substituted Indenes (Chem. Eur. J. 41/2016)
Author(s) -
Preinfalk Alexander,
Misale Antonio,
Maulide Nuno
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604243
Subject(s) - domino , catalysis , indene , chemistry , cascade reaction , cascade , coupling (piping) , combinatorial chemistry , cover (algebra) , medicinal chemistry , photochemistry , organic chemistry , materials science , chromatography , metallurgy , mechanical engineering , engineering
The domino coupling of alcohols with allenes is reported. In this transformation, a gold catalyst orchestrates the sequential cyclization and C−C coupling of aromatic allenes and benzylic alcohols to generate indene products in high yields. This reaction cascade proceeds with water as the only by‐product and does not need strict exclusion of moisture or oxygen. More information can be found in the Communication by N. Maulide et al. on page 14471 ff.