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Influence of the Headgroup of Azolium‐Based Lipids on Their Biophysical Properties and Cytotoxicity
Author(s) -
Rühling Andreas,
Wang Da,
Ernst Johannes B.,
Wulff Stephanie,
Honeker Roman,
Richter Christian,
Ferry Angélique,
Galla HansJoachim,
Glorius Frank
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604182
Subject(s) - cytotoxicity , derivative (finance) , differential scanning calorimetry , chemistry , biophysics , stereochemistry , membrane , fluorescence microscope , fluorescence , combinatorial chemistry , biochemistry , in vitro , biology , physics , economics , financial economics , thermodynamics , quantum mechanics
A series of (un‐)charged NHC derivatives bearing two pentadecyl chains in the backbone was studied in detail to find cooperative effects between the membrane and the NHC derivative. The tendency to show lipid‐like behavior is dependent on the properties of the NHC derivative headgroup, which can be modified on demand. The surface activity was investigated by film balance measurements, epifluorescence microscopy, and differential scanning calorimetry. Additionally the cytotoxicity was evaluated against different cell lines such as eukaryotic tumor cell lines. These novel lipid‐like NHC derivatives offer a broad spectrum for biological applications.