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Cobalt(III)‐Catalyzed Intramolecular Cross‐Dehydrogenative C−H/X−H Coupling: Efficient Synthesis of Indoles and Benzofurans
Author(s) -
Ghorai Jayanta,
Reddy Angula Chandra Shekar,
Anbarasan Pazhamalai
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604111
Subject(s) - intramolecular force , cobalt , catalysis , chemistry , coupling (piping) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , metallurgy
An efficient cobalt(III)‐catalyzed intramolecular cross‐dehydrogenative C−H/N−H coupling of ortho ‐alkenylanilines has been developed utilizing O 2 as a terminal oxidant. The developed reaction tolerates various reactive functional groups and allows the synthesis of diverse indole derivatives in good to excellent yields. The method was successfully extended to the synthesis of benzofurans through the intramolecular cross‐dehydrogenative C−H/O−H coupling of ortho ‐alkenylphenols.