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Self‐Regulated Glucose‐Sensitive Neoglycoenzyme‐Capped Mesoporous Silica Nanoparticles for Insulin Delivery
Author(s) -
Oroval Mar,
Díez Paula,
Aznar Elena,
Coll Carmen,
Marcos María Dolores,
Sancenón Félix,
Villalonga Reynaldo,
MartínezMáñez Ramón
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604104
Subject(s) - glucose oxidase , mesoporous silica , insulin , fluorescein isothiocyanate , chemistry , benzimidazole , gluconic acid , mesoporous material , nanoparticle , insulin delivery , organic chemistry , nanotechnology , materials science , diabetes mellitus , medicine , endocrinology , catalysis , fluorescence , enzyme , physics , quantum mechanics , type 1 diabetes
We describe herein the preparation of glucose‐sensitive capped mesoporous silica nanoparticles for insulin delivery. The new material consists of an expanded‐pore nanometric silica support grafted with 1‐propyl‐1‐ H ‐benzimidazole groups, loaded with fluorescein isothiocyanate‐labeled insulin (FITC‐Ins) and capped by the formation of inclusion complexes between cyclodextrin‐modified glucose oxidase (CD‐GOx) and the benzimidazole groups grafted on the mesoporous support. Insulin delivery from the gated material in simulated blood plasma was assessed upon addition of glucose. Glucose is transformed by GOx into gluconic acid, which promoted the dethreading of the benzimidazole–CD‐GOx inclusion complexes, allowing cargo release. Small quantities of this support would be needed to release the amount of insulin necessary to decrease diabetic blood glucose concentrations to regular levels.