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Mechanism and Scope of Base‐Controlled Catalyst‐Free N‐Arylation of Amines with Unactivated Fluorobenzenes
Author(s) -
Borch Jacobsen Christian,
Meldal Morten,
Diness Frederik
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604098
Subject(s) - scope (computer science) , base (topology) , mechanism (biology) , chemistry , catalysis , combinatorial chemistry , computer science , organic chemistry , physics , mathematics , programming language , mathematical analysis , quantum mechanics
A general method for transition metal‐free N ‐arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two‐step synthesis of the antidepressant Vortioxetine.