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Pd‐Catalyzed Carboamination of Alkylidenecyclopropanes: Synthesis of Congested Pyrrolidines and Piperidines
Author(s) -
Lazzara Phillip R.,
Fitzpatrick Keegan P.,
Eichman Chad C.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604077
Subject(s) - pyrrolidine , piperidine , catalysis , chemistry , organic chemistry , combinatorial chemistry
The synthesis of densely functionalized N‐heterocycles is an ongoing challenge in chemical synthesis. Herein, we report an efficient method for the construction of pyrrolidine and piperidine scaffolds using a palladium‐catalyzed carboamination of alkylidenecyclopropanes.