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Domino Staudinger/ aza ‐Wittig/Mannich Reaction: An Approach to Diversity of Di‐ and Tetrahydropyrrole Scaffolds
Author(s) -
Pavlova Anna S.,
Ivanova Olga A.,
Chagarovskiy Alexey O.,
Stebunov Nikolay S.,
Orlov Nikolay V.,
Shumsky Alexey N.,
Budynina Ekaterina M.,
Rybakov Victor B.,
Trushkov Igor V.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201604056
Subject(s) - domino , chemistry , mannich reaction , combinatorial chemistry , wittig reaction , cascade reaction , thio , reaction conditions , organic chemistry , functional group , catalysis , polymer
A highly efficient and selective domino reaction producing valuable di‐ and tetrahydropyrrole‐based skeletons from azidoethyl‐substituted CH‐acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three‐ and polycyclic azaheterocyclic scaffolds was demonstrated.