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Production of Pure Aqueous 13 C‐Hyperpolarized Acetate by Heterogeneous Parahydrogen‐Induced Polarization
Author(s) -
Kovtunov Kirill V.,
Barskiy Danila A.,
Shchepin Roman V.,
Salnikov Oleg G.,
Prosvirin Igor P.,
Bukhtiyarov Andrey V.,
Kovtunova Larisa M.,
Bukhtiyarov Valerii I.,
Koptyug Igor V.,
Chekmenev Eduard Y.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603974
Subject(s) - spin isomers of hydrogen , chemistry , induced polarization , aqueous solution , hyperpolarization (physics) , catalysis , polarization (electrochemistry) , metal , hydrogen , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , electrical engineering , electrical resistivity and conductivity , engineering
A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce 13 C‐hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO 2 catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized 13 C‐enriched ethyl acetate‐1‐ 13 C detected at 9.4 T. An approximately 14‐fold 13 C signal enhancement was detected using circa 50 % parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen‐derived protons to 13 C nuclei. This first observation of 13 C PHIP‐hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst‐free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP‐SAH) approach.