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Mg II ‐Catalyzed Desymmetrization Reaction of meso ‐Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2‐Diamine Skeletons
Author(s) -
Li Dan,
Yang Dongxu,
Wang Linqing,
Liu Xihong,
Jiang Xianxing,
Wang Rui
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603898
Subject(s) - desymmetrization , diamine , catalysis , chemistry , aziridine , medicinal chemistry , polymer chemistry , organic chemistry , enantioselective synthesis , ring (chemistry)
A Mg II ‐catalyzed desymmetrization reaction of meso ‐aziridines with hydroxylamines has been disclosed for the first time. A series of novel chiral 1,2‐diamine skeletons were obtained in good yields and enantioselectivities. The reaction employed magnesium catalysis generated in situ from a simple oxazoline‐OH chiral ligand. Obviously, the diverse structures of the obtained chiral 1,2‐diamine compounds could allow them to be potential chiral ligands in future catalytic asymmetric synthesis studies.