Cover Picture: A Ligand That Targets CUG Trinucleotide Repeats (Chem. Eur. J. 42/2016) | Zendy

Li Jinxing | Zendy; Matsumoto Jun | Zendy; Bai LiPing | Zendy; Murata Asako | Zendy; Dohno Chikara | Zendy; Nakatani Kazuhiko | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Cover Picture: A Ligand That Targets CUG Trinucleotide Repeats (Chem. Eur. J. 42/2016)

Author(s) -

Li Jinxing,

Matsumoto Jun,

Bai LiPing,

Murata Asako,

Dohno Chikara,

Nakatani Kazuhiko

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201603856

Subject(s) - myotonic dystrophy , trinucleotide repeat expansion , genetics , translation (biology) , biology , in vitro , microbiology and biotechnology , gene , messenger rna , allele

The expansion of trinucleotide repeat sequences in human genome is known as causatives of more than 40 hereditary neurological disorders. The mechanism of the Myotonic Dystrophy Type 1 (DM1) disorder involves a gain‐of‐function model due to a toxic RNA of the expanded r(CUG) n repeats. The dual luciferase assay indicated that binding of this molecule to the r(CUG) n repeat affected the translation in vitro. More information can be found on page 14881 ff. in the Full Paper by K. Nakatani et al.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research