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Inside Back Cover: Supramolecular Self‐Assembly of Histidine‐Capped‐Dialkoxy‐Anthracene: A Visible‐Light‐Triggered Platform for Facile siRNA Delivery (Chem. Eur. J. 39/2016)
Author(s) -
Patil Sachin P.,
Moosa Basem A.,
Alsaiari Shahad,
Alamoudi Kholod,
Alshamsan Aws,
AlMalik Abdulaziz,
Adil Karim,
Eddaoudi Mohamed,
Khashab Niveen M.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603686
Subject(s) - linker , anthracene , singlet oxygen , chemistry , histidine , supramolecular chemistry , photochemistry , materials science , combinatorial chemistry , organic chemistry , oxygen , computer science , crystal structure , enzyme , operating system
A 9,10‐dialkoxy‐substituted anthracene linker has been designed and synthesized and used as a light‐responsive platform to deliver siRNA. The histidine‐substituted linker self‐assembled in the presence of RNA forming a smart and biocompatible delivery capsule. This process is mediated by singlet oxygen, which cleaves the dialkoxyanthracene linker leading to the knocking down of Bcl‐2 gene expression with up to 90% in live cells. More information can be found in the Communication by N. M. Khashab et al. on page 13789 ff.