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Acidic Co‐Catalysts in Cationic Gold Catalysis
Author(s) -
Barrio Pablo,
Kumar Manish,
Lu Zhichao,
Han Junbin,
Xu Bo,
Hammond Gerald B.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603478
Subject(s) - catalysis , cationic polymerization , nucleophile , chemistry , lewis acids and bases , synergistic catalysis , organic chemistry
A systematic study on the effects of Lewis or Brønsted acid co‐catalysts in gold‐catalyzed reactions was undertaken using representative reactions (O‐, N‐, and C‐nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co‐catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings (<1 mol %). Further investigation is currently underway to improve the understanding of the subtle principles underlying these experimental observations.