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Inside Cover: A Trimodal Closomer Drug‐Delivery System Tailored with Tracing and Targeting Capabilities (Chem. Eur. J. 36/2016)
Author(s) -
Sarma Saurav J.,
Khan Aslam A.,
Goswami Lalit N.,
Jalisatgi Satish S.,
Hawthorne M. Frederick
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603415
Subject(s) - chlorambucil , drug delivery , cytotoxicity , targeted drug delivery , drug , payload (computing) , chemistry , nanotechnology , cancer research , pharmacology , materials science , computer science , biochemistry , medicine , computer network , chemotherapy , network packet , in vitro , cyclophosphamide
A monodisperse drug delivery nanostructure based on a polyhedral borane scaffold, featuring diagnostic and targeting functionalities, delivers high‐payload of the anticancer agent Chlorambucil selectively to cancer cells, mediated through GLUT‐1 receptors. This results in enhanced cytotoxicity compared to the non‐targeted parent drug. Furthermore, it was found to localize in the mitochondria of the cell rather than in the nucleus, raising hopes for combating drug resistance associated with Chlorambucil. More information can be found in the Full Paper by M. F. Hawthorne et al. on page 12715.