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Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch
Author(s) -
Basílio Nuno,
Pischel Uwe
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603331
Subject(s) - photoswitch , photochromism , chalcone , supramolecular chemistry , cucurbituril , host (biology) , chemistry , drug delivery , memantine , photochemistry , combinatorial chemistry , stereochemistry , organic chemistry , molecule , biochemistry , receptor , ecology , nmda receptor , biology
Abstract The reversibly switchable trans ‐chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug‐cucurbit[7]uril host–guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.