Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch | Zendy

Basílio Nuno | Zendy; Pischel Uwe | Zendy

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Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch

Author(s) -

Basílio Nuno,

Pischel Uwe

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201603331

Subject(s) - photoswitch , photochromism , chalcone , cucurbituril , supramolecular chemistry , host (biology) , chemistry , drug delivery , drug , photochemistry , combinatorial chemistry , stereochemistry , organic chemistry , molecule , pharmacology , medicine , ecology , biology

The reversibly switchable trans ‐chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug‐cucurbit[7]uril host–guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.

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