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Tumour‐Targeted Drug Delivery with Mannose‐Functionalized Nanoparticles Self‐Assembled from Amphiphilic β‐Cyclodextrins
Author(s) -
Ye Zhou,
Zhang Quan,
Wang Shengtao,
Bharate Priya,
VarelaAramburu Silvia,
Lu Mengji,
Seeberger Peter H.,
Yin Jian
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603294
Subject(s) - endocytosis , mannose , drug delivery , targeted drug delivery , chemistry , amphiphile , doxorubicin , mannose receptor , in vivo , cancer cell , intracellular , drug carrier , cancer , cancer research , pharmacology , cell , biochemistry , in vitro , chemotherapy , medicine , biology , copolymer , organic chemistry , microbiology and biotechnology , macrophage , polymer
Multivalent mannose‐functionalized nanoparticles self‐assembled from amphiphilic β‐cyclodextrins (β‐CDs) facilitate the targeted delivery of anticancer drugs to specific cancer cells. Doxorubicin (DOX)‐loaded nanoparticles equipped with multivalent mannose target units were efficiently taken up via receptor‐mediated endocytosis by MDA‐MB‐231 breast cancer cells that overexpress the mannose receptor. Upon entering the cell, the intracellular pH causes the release of DOX, which triggers apoptosis. Targeting by multivalent mannose significantly improved the capability of DOX‐loaded nanoparticles to inhibit the growth of MDA‐MB‐231 cancer cells with minimal side effects in vivo. This targeted and controlled drug delivery system holds promise as a nanotherapeutic for cancer treatment.