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On‐Demand Release of Hydrosoluble Drugs from a Paramagnetic Porous Collagen‐Based Scaffold
Author(s) -
Bettini Simona,
Bonfrate Valentina,
Madaghiele Marta,
Salvatore Luca,
Syrgiannis Zois,
Giancane Gabriele,
Valli Ludovico
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603210
Subject(s) - microporous material , biomaterial , myoglobin , scaffold , materials science , controlled release , porosity , nanotechnology , chemistry , biophysics , chemical engineering , biomedical engineering , biochemistry , composite material , medicine , engineering , biology
Abstract The design of a collagen scaffold containing iron oxide nanostructures capped by a TiO 2 (anatase) layer is reported. The TiO 2 shell is proposed to perform a dual role: 1) as an innovative and biocompatible cross‐linker agent, providing binding sites to the protein moiety, through the well‐known TiO 2 chemical affinity towards carboxyl groups, and 2) as a protective surface layer for the paramagnetic core against oxidation. Simultaneously, the presence of the nanostructures confers to the collagen gel sensitivity to an external stimulus; that is, the application of a magnetic field. The hybrid biomaterial was demonstrated to be nontoxic and is proposed as a smart scaffold for the release of bioactive compounds on demand. The tuneable release of a model protein (myoglobin) upon application of a magnetic field was investigated. Myoglobin was loaded in the microporous material and discharge was induced by consecutive magnet applications, leading to release of the protein with high spatio–temporal and dosage control.