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A New Generation of Smart Amine Donors for Transaminase‐Mediated Biotransformations
Author(s) -
Gomm Andrew,
Lewis William,
Green Anthony P.,
O'Reilly Elaine
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603188
Subject(s) - cadaverine , transaminase , decarboxylation , combinatorial chemistry , amine gas treating , chemistry , diamine , biotransformation , putrescine , organic chemistry , enzyme , catalysis
The application of ω‐transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effective approach using low equivalents of the new diamine donor, cadaverine, which enables high conversions of challenging substrates to the corresponding chiral amines in excellent ee . This approach paves the way for the design of self‐sufficient fermentation processes combining transaminase biotransformations with existing strategies for cadaverine production by decarboxylation of endogenous lysine.