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A Gold(I)‐Catalyzed Domino Coupling of Alcohols with Allenes Enables the Synthesis of Highly Substituted Indenes
Author(s) -
Preinfalk Alexander,
Misale Antonio,
Maulide Nuno
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603154
Subject(s) - domino , catalysis , coupling (piping) , chemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , metallurgy
Abstract The reaction of aryl‐substituted allenes with alcohols under gold catalysis led to highly substituted indenes in good yields, with low catalyst loading and under mild conditions. During this domino transformation, two C−C bonds are formed with water as the only byproduct.