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TBAI‐Catalyzed/Water‐Assisted Double C−S Bond Formations: An Efficient Approach to Sulfides through Metal‐Free Three‐Component Reactions
Author(s) -
Chu XueQiang,
Xu XiaoPing,
Ji ShunJun
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603099
Subject(s) - sodium thiosulfate , catalysis , halide , chemistry , thiosulfate , aqueous solution , environmentally friendly , double bond , alcohol , sodium iodide , organic chemistry , combinatorial chemistry , inorganic chemistry , sulfur , ecology , biology
An aqueous catalytic method for double C−S bond formations that involves alcohol derivatives, organic halides, and sodium thiosulfate has been developed. A diverse range of functionalized sulfides, including pharmaceutical and biological derivatives, can be obtained in an efficient and eco‐friendly manner under air. The mechanistic studies revealed that this tetrabutylammonium‐iodide‐catalyzed/water‐assisted reaction generated a mercaptan species as the key intermediate.