TBAI‐Catalyzed/Water‐Assisted Double C−S Bond Formations: An Efficient Approach to Sulfides through Metal‐Free Three‐Component Reactions | Zendy

Chu XueQiang | Zendy; Xu XiaoPing | Zendy; Ji ShunJun | Zendy

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TBAI‐Catalyzed/Water‐Assisted Double C−S Bond Formations: An Efficient Approach to Sulfides through Metal‐Free Three‐Component Reactions

Author(s) -

Chu XueQiang,

Xu XiaoPing,

Ji ShunJun

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201603099

Subject(s) - sodium thiosulfate , catalysis , halide , chemistry , thiosulfate , aqueous solution , environmentally friendly , double bond , alcohol , sodium iodide , organic chemistry , combinatorial chemistry , inorganic chemistry , sulfur , ecology , biology

An aqueous catalytic method for double C−S bond formations that involves alcohol derivatives, organic halides, and sodium thiosulfate has been developed. A diverse range of functionalized sulfides, including pharmaceutical and biological derivatives, can be obtained in an efficient and eco‐friendly manner under air. The mechanistic studies revealed that this tetrabutylammonium‐iodide‐catalyzed/water‐assisted reaction generated a mercaptan species as the key intermediate.

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