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Nickel‐Catalyzed C−H Chalcogenation of Anilines
Author(s) -
Müller Thomas,
Ackermann Lutz
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603092
Subject(s) - aniline , catalysis , nickel , chemistry , ligand (biochemistry) , scope (computer science) , combinatorial chemistry , aniline compounds , functional group , organic chemistry , receptor , biochemistry , computer science , programming language , polymer
The C−H thiolation of aniline derivatives was accomplished with a versatile nickel(II) catalyst under ligand‐free conditions. The robust nature of the nickel catalysis system was reflected by the C−H thiolation with a good functional group tolerance and an ample scope, employing anilines possessing removable directing groups. The widely applicable nickel catalyst also allowed for aniline C−H selenylations, while mechanistic studies provided strong support that the rate‐determining step is the C−H activation.