Premium
A Flexible Terpyridine Derivative Interacts Specifically with G‐Quadruplexes
Author(s) -
De Rache Aurore,
Gueddouda Nassima Meriem,
Bourdoncle Anne,
Hommes Paul,
Reissig HansUlrich,
Mergny JeanLouis
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603021
Subject(s) - terpyridine , g quadruplex , nucleic acid , circular dichroism , chemistry , helicase , förster resonance energy transfer , derivative (finance) , stereochemistry , ligand (biochemistry) , dna , combinatorial chemistry , biophysics , biochemistry , rna , biology , metal , fluorescence , organic chemistry , financial economics , physics , receptor , quantum mechanics , economics , gene
G‐quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi‐ and terpyridine derivatives with G‐quadruplexes and duplexes. FRET‐melting, circular dichroism, and 1 H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G‐quadruplexes. This G‐quadruplex ligand inhibited helicase activity and should influence G‐quadruplex‐related biological processes.