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Room‐Temperature Gold‐Catalysed Arylation of Heteroarenes: Complementarity to Palladium Catalysis
Author(s) -
Cresswell Alexander J.,
LloydJones Guy C.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602893
Subject(s) - palladium , catalysis , complementarity (molecular biology) , chemistry , organic chemistry , biology , genetics
Tailoring of the pre‐catalyst, the oxidant and the arylsilane enables the first room‐temperature, gold‐catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.
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