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Near‐Infrared‐Emitting BODIPY‐trisDOTA 111 In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations
Author(s) -
Maindron Nicolas,
Ipuy Martin,
Bernhard Claire,
Lhenry Damien,
Moreau Mathieu,
Carme Sabin,
Oudot Alexandra,
Collin Bertrand,
Vrigneaud JeanMarc,
Provent Peggy,
Brunotte François,
Denat Franck,
Goze Christine
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602886
Subject(s) - bodipy , in vivo , fluorescence , bioconjugation , conjugated system , chemistry , dota , molecular imaging , fluorescence lifetime imaging microscopy , yield (engineering) , preclinical imaging , boron , biodistribution , materials science , chelation , combinatorial chemistry , organic chemistry , in vitro , biochemistry , optics , physics , microbiology and biotechnology , metallurgy , biology , polymer
A new generation of monomolecular imaging probes (MOMIP) based on a distyryl‐BODIPY (BODIPY=boron‐dipyrromethene) coupled with three DOTA macrocycles has been prepared (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid). The MOMIP presents good fluorescence properties and is very stable in serum. The bimodal probe was conjugated to trastuzumab, and an optical in vivo study showed high accumulation of the imaging agent at the tumor site. 111 In radiometallation of the bioconjugate was performed in high radiochemical yield, highlighting the potential of this new BODIPY‐chelators derivative as a bimodal imaging probe.