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Nickel‐Promoted Recognition of Long DNA Sites by Designed Peptide Derivatives
Author(s) -
Rodríguez Jéssica,
Mosquera Jesús,
Vázquez M. Eugenio,
Mascareñas José L.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602783
Subject(s) - dna , chelation , combinatorial chemistry , nickel , peptide , chemistry , transcription (linguistics) , bipyridine , stereochemistry , base pair , metal , computational biology , biochemistry , biology , crystallography , organic chemistry , philosophy , linguistics , crystal structure
We describe the synthesis of designed peptidic modules that self‐assemble in specific DNA sequences of 12 base pairs in the presence of Ni II salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal‐chelating His and bipyridine ligands.