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Palladium(0)‐Catalyzed Intermolecular Allylic Dearomatization of Indoles by a Formal [4+2] Cycloaddition Reaction
Author(s) -
Gao RunDuo,
Xu QingLong,
Zhang Bo,
Gu Yiting,
Dai LiXin,
You ShuLi
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602691
Subject(s) - allylic rearrangement , intermolecular force , chemistry , catalysis , nucleophile , indoline , palladium , alcohol , cycloaddition , allylic alcohol , medicinal chemistry , organic chemistry , molecule
Bridged indoline derivatives were synthesized by an intermolecular Pd‐catalyzed allylic dearomatization reaction of substituted indoles. The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side‐chain proceeds in a cascade fashion, providing bridged indolines in excellent enantioselectivity.