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A Sustainable, Semi‐Continuous Flow Synthesis of Hydantoins
Author(s) -
Vukelić Stella,
Koksch Beate,
Seeberger Peter H.,
Gilmore Kerry
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602609
Subject(s) - reagent , continuous flow , chemistry , organic synthesis , combinatorial chemistry , flow chemistry , process (computing) , organic chemistry , computer science , process engineering , biochemical engineering , catalysis , engineering , programming language
Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas–liquid transformations (oxygen, carbon dioxide). This semi‐continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52–84 %).