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A Pd‐Catalyzed Synthesis of Functionalized Piperidines
Author(s) -
Allen Benjamin D. W.,
Connolly Matthew J.,
Harrity Joseph P. A.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602586
Subject(s) - piperidine , annulation , catalysis , carbamate , combinatorial chemistry , chemistry , organic chemistry
A readily available cyclic carbamate 1 functions as a general precursor to a range of functionalized piperidine products via a new Pd‐catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration.