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Electrochemical Oxidative C−H/N−H Coupling between γ‐Lactams and Anilines
Author(s) -
Gong Ming,
Huang JingMei
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602454
Subject(s) - electrochemistry , anode , oxidative coupling of methane , catalysis , oxidative phosphorylation , current density , chemistry , combinatorial chemistry , metal , coupling (piping) , materials science , organic chemistry , electrode , metallurgy , biochemistry , physics , quantum mechanics
A mild method for the direct C−H/N−H coupling between γ‐lactams and anilines through electrochemical oxidation has been developed. The protocol proceeded smoothly without metal catalysts at room temperature to afford γ‐substituted γ ‐ lactams in good yields. It has been revealed that the quasi‐divided cell which provided high current density on the anode was crucial for this reaction.