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pH‐Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
Author(s) -
AríñezSoriano Javier,
Albalad Jorge,
CarnéSánchez Arnau,
Bonnet Célia S.,
Busqué Félix,
Lorenzo Julia,
Juanhuix Jordi,
Terban Maxwell W.,
Imaz Inhar,
Tóth Éva,
Maspoch Daniel
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602356
Subject(s) - lanthanide , gadolinium , chelation , dota , polymer , nanoparticle , nanoscopic scale , chemistry , leaching (pedology) , metal , materials science , nuclear chemistry , chemical engineering , inorganic chemistry , nanotechnology , ion , organic chemistry , environmental science , soil science , soil water , engineering
Lanthanide‐containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gd III chelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd‐DOTA‐4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r 1 =16.4 m m −1 s −1 at 10 MHz), but also for a pH responsiveness (Δ r 1 =108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd‐DOTA‐4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.