Premium
Palladium‐Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine‐Containing Molecules at Room Temperature
Author(s) -
AlShuaeeb Riyadh Ahmed Atto,
Kolodych Sergii,
Koniev Oleksandr,
Delacroix Sébastien,
Erb Stéphane,
Nicolaÿ Stéphanie,
Cintrat JeanChristophe,
Brion JeanDaniel,
Cianférani Sarah,
Alami Mouâd,
Wagner Alain,
Messaoudi Samir
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602277
Subject(s) - bioconjugation , surface modification , xantphos , catalysis , combinatorial chemistry , chemistry , cysteine , palladium , biocompatible material , thiol , organic chemistry , enzyme , biomedical engineering , medicine
The third generation of aminobiphenyl palladacycle pre‐catalyst “G3‐Xantphos” enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.