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Chemo‐ and Regioselective Rhodium(I)‐Catalyzed [2+2+2] Cycloaddition of Allenynes with Alkynes
Author(s) -
Yasuda Shigeo,
Kawaguchi Yasuaki,
Okamoto Yuta,
Mukai Chisato
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602239
Subject(s) - regioselectivity , rhodium , cycloaddition , intramolecular force , catalysis , chemistry , benzene , medicinal chemistry , combinatorial chemistry , organic chemistry
A highly chemo‐ and regioselective partially intramolecular rhodium(I)‐catalyzed [2+2+2] cycloaddition of allenynes with alkynes is described. A range of diverse polysubstituted benzene derivatives could be synthesized in good to excellent yields, in which the allenynes served as synthetic equivalent to the diynes. A high regioselectivity could be observed when allenynes were treated with unsymmetrical alkynes.