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A Highly Selective Fluorescence Turn‐On Sensor for Extracellular Calcium Ion Detection
Author(s) -
Sui Binglin,
Liu Xinglei,
Wang Mengyuan,
Belfield Kevin D.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602162
Subject(s) - fluorescence , turn (biochemistry) , extracellular , calcium , ion , chemistry , biophysics , biochemistry , biology , optics , physics , organic chemistry
A highly water‐soluble, fluorescence turn‐on sensor for Ca 2+ is reported. The sensor affords high selectivity in sensing Ca 2+ over other biologically important metal cations. The dissociation constant of the sensor in binding Ca 2+ is 0.92 m m . Fluorescence microscopy experiments demonstrate that the sensor is cell‐impermeable and capable of detecting extracellular Ca 2+ .